Los Angeles Chargers head coach Jim Harbaugh briefly left the field because of a heart arrhythmia during his team’s win, but returned to watch his defence dominate the Broncos and threaten a first home shutout in Denver – until the hosts made a game of it in the fourth quarter.

Having AJ Brown back gave the Philadelphia Eagles a big spark on offence but, even with his 116 receiving yards and a touchdown, they could have been in trouble had Deshaun Watson not underwhelmed again for the Cleveland Browns.

Tennessee’s Will Levis also underwhelmed with only 95 passing yards against the injury-hit Indianapolis Colts and the league’s most porous defence, leaving the Titans with a decision to make at quarterback.

Despite Justin Fields running in two more touchdowns as the Steelers beat the Raiders in front of plenty of Pittsburgh fans in Las Vegas, with his throwing still inconsistent there could also be another quarterback change with Russell Wilson waiting in the wings.

Joe Burrow produced a career-long 47-yard touchdown run and saw his defence finally show up as the Cincinnati Bengals salvaged their season with a 17-7 win at the New York Giants.

Kirk Cousins passed for more than 500 yards last week, but the run game powered the Atlanta Falcons this time around as they rushed for 198 yards and three touchdowns to see off the Panthers.