Sinner, ranked No 1, will play Russian Daniil Medvedev, the No 5 seed, next.
In the previous rounds of the US Open, the Italian won against American Mackenzie McDonald (2-6, 6-2, 6-1, 6-2), American Alex Michelsen (6-4, 6-0, 6-2) and Australian Christopher O’Connell (6-1, 6-4, 6-2).
Paul, ranked No 14, won against Italian Lorenzo Sonego (6-4, 6-2, 5-7, 6-2), Australian Max Purcell (7-5, 6-0, 1-0 ret.) and Canadian qualifier Gabriel Diallo (6-7 (5), 6-3, 6-1, 7-6 (3)) earlier in the tournament.
New York (Grand Slam), other last 16 results (USTA Billie Jean King National Tennis Center, hard, USD 75.000.000, most recent results first):
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